Tuesday, April 21, 2026

Best 49ers vs. Colts Player Prop Bets: Target Josh Downs, Brock Purdy

The highly anticipated matchup between the San Francisco 49ers and the Indianapolis Colts is finally here, and football fans are eagerly waiting to see who will come out on top. As the two teams battle it out on the field, there are plenty of opportunities for fans to get in on the action and make the game even more exciting. One way to do that is by placing player prop bets, and there are plenty of options to choose from. In this article, we’ll take a look at the top 49ers vs. Colts player prop bets to consider, with a special focus on wide receiver Josh Downs and his potential to exceed his receptions total.

1. Josh Downs to go over his receptions total
Josh Downs has been a key player for the 49ers this season, and he has consistently shown his ability to make big plays. In the last game against the Green Bay Packers, Downs had a total of 9 receptions, which was well above his season average of 6.5 receptions per game. With the Colts’ defense struggling to contain opposing receivers, Downs has a great chance to go over his receptions total once again. This bet is definitely worth considering, especially with the way Downs has been performing lately.

2. Deebo Samuel to have the most receiving yards
Deebo Samuel has been a standout player for the 49ers this season, and he has been a consistent threat in the passing game. In the last game against the Packers, Samuel had a total of 52 receiving yards, which was below his season average of 82.3 yards per game. However, with the Colts’ defense struggling to defend against the pass, Samuel has a great chance to have the most receiving yards in this game. This bet is definitely worth considering, especially with Samuel’s ability to make big plays.

3. Jonathan Taylor to score a touchdown
Jonathan Taylor has been a force to be reckoned with for the Colts this season, and he has consistently found the end zone. In the last game against the Tennessee Titans, Taylor had a total of 2 touchdowns, bringing his season total to 10. With the 49ers’ defense struggling to stop the run, Taylor has a great chance to score a touchdown in this game. This bet is definitely worth considering, especially with Taylor’s impressive track record this season.

4. George Kittle to have over 100 receiving yards
George Kittle has been a reliable target for the 49ers this season, and he has consistently put up big numbers. In the last game against the Packers, Kittle had a total of 92 receiving yards, which was just shy of his season average of 98.1 yards per game. With the Colts’ defense struggling to defend against tight ends, Kittle has a great chance to have over 100 receiving yards in this game. This bet is definitely worth considering, especially with Kittle’s ability to make big plays.

5. Carson Wentz to throw for over 250 yards
Carson Wentz has been a solid quarterback for the Colts this season, and he has consistently put up good numbers. In the last game against the Titans, Wentz threw for a total of 225 yards, which was below his season average of 243.2 yards per game. However, with the 49ers’ defense struggling to defend against the pass, Wentz has a great chance to throw for over 250 yards in this game. This bet is definitely worth considering, especially with Wentz’s ability to make accurate throws.

6. Nick Bosa to record a sack
Nick Bosa has been a dominant force for the 49ers’ defense this season, and he has consistently put pressure on opposing quarterbacks. In the last game against the Packers, Bosa recorded a total of 2 sacks, bringing his season total to 7.5. With the Colts’ offensive line struggling to protect Carson Wentz, Bosa has a great chance to record a sack in this game. This bet is definitely worth considering, especially with Bosa’s ability to disrupt the opposing team’s offense.

7. Michael Pittman Jr. to have over 75 receiving yards
Michael Pittman Jr. has been a reliable target for the Colts this season, and he has consistently put up good numbers. In the last game against the Titans, Pittman Jr. had a total of 68 receiving yards, which was just shy of his season average of 77.

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